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KMID : 0358419620050020011
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Korean Journal of Obstetrics and Gynecology
1962 Volume.5 No. 2 p.11 ~ p.18
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Trophoblastic Tumors Preliminary Report
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黃泰植/Hwang, Tae.Sik.
盧庚昞/金斗浩/Roh, Gyung.Byung./Kim, Doo.Ho.
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Abstract
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This article is a preliminary report of the Yonsei University College of Medicine, from June 1. 1959 to July 30. 1961. A total of 20 cases were seen with the following distribution; Hydatiform mole 12, chorioadenoma destruens 1, choriocarcinoma 7.
The following features were noted among the patients with hydatiform mole. One case as under age 25 and one case over 40 with all the rest between the ages of 25-30. In the majority 1f patients there was a lapse of three months from the L.M.P. till the mole was passed but the shortest was 25 days and the longest was 155 days. 75% of the patients had a fever and at least 5 % had a chilly sensation. Half the cases when first seen had uterine enlargement greater than erected by dates while 33% were consistent with their dates and the result were smaller than their dates.
Toxemia was seen in 33% of the patients. One third of the patients who were less than 4 months pregnant or whose uterus was below the umbilicus had toxemia. Of the two cases who were more than 4 months pregnant or whose uterus was enlarged above the umbilicus, one of them developed toxemia. 25% of the patients developed theca leutein cysts.
The patients were managed by either pitocin induction or stimulation followed by a D&C. In one patient over 40 a hysterectomy was carried out after passage of the mole. The remaining l patients were followed according to the chart seen in fig. 9 of the main article.
The patients with choriocarcinoma ranged in age from 23 to 52 with three patients over 48 years old. The vast majority were multiparas. Four of the patients had a previous history of Passing a mole and in the others there had been a normal delivery. None of the patients had had an abortion.: Among the patients who passed a mole the diagnosis of carcinoma was made in one patient within 25 days and in the remainder before 10 months. Among the three patients who had had a normal pregnancy there was a time interval of 3 years in one case and 9 years in two cases. Theca lutein cysts were found in 3 cases. The Friedman test was positive in 100%. Metastatic lesions we e found in the lungs in 57%, the vagina in 57% and in the broad ligament in 14%.
A total abdominal hysterectomy and bilateral salpingoophorectomy was done in 4 patients. ´IA combination of external rediotherapy and chemotherapy was tried in one case and no therapy was given in 2 cases. At present 2 patients have died, 3 are alive and well, and 2 have been lost to follow up.
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